iPrescribe: Activate My Account for EPCS

You must activate your iPrescribe account to prescribe controlled substances electronically. After, you must then confirm your Electronic Prescribing of Controlled Substances (EPCS) activation.

This article assumes you have created your account in iPrescribe and successfully completed identity proofing through ID.me. To learn more, see: Register for iPrescribe
If you experience any difficulties creating your account please click to submit a ticket to the iPrescribe Support Team

1. Prerequisites

Before you begin, you will need to have the following ready:

  • The mobile device you intend to use for e-prescribing
  • Your NPI number
  • Your DEA number 
  • First and last name
  • Email address (of a person to provide as reference to confirm your access to EPCS)
  • Update the DEA profile with your current business mailing address. Reminder that the address used will be the primary business address listed on your DEA profile. 


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2. Activate My Account for EPCS

1. Select the option to activate for e-prescribing controlled substances.

2. On the next screen, tap Continue to proceed.

  • Tap Remind me later if you'd like to activate but aren't able to at the moment. 
  • Tap I don't want to prescribe controlled substances to opt-out of future prompts to activate your account. You can always revisit this later.
  • If you leave the activation process and come back, iPrescribe will pick up where you left off.

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3. Tap Go to the app store. You will be redirected to the ID.me Authenticator app on the app store page. Install the ID.me Authenticator app on your phone if you have not already done so.

  • Go back and open your iPrescribe application, then tap Yes when prompted.


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4. Make sure your Mailing Address, City, State, and Zip code are accurate. You may update the address to have the free code generating device (token) shipped to a different location.

5. Tap the Get code generator button to continue.

We will send a physical code generating device (token) to the address provided. When you receive the token, you will need to add it to your iPrescribe account by following the instructions received with the fob.

  • To prescribe controlled substances electronically, the DEA requires you to provide a unique code in addition to providing your password.

6. Tap Invite reference, then enter their First NameLast Name, and Email. Tap Continue to proceed.

  • The DEA requires a reference to verify your identity before you can prescribe controlled substances. This is a one-time action and takes less than a minute for your reference to authorize you.

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7. Tap Open instructions and follow the on-screen instructions.

  • You must click 'Open instructions in browser' to be able to click the 'Sign into ID.me' box.
  • You will be taken into a web browser outside of the iPrescribe application. If you are on an iPhone, you can close the web browser by selecting the done button on the bottom left hand corner of the screen to come back to this page.


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8. Enter your NPI Number and DEA Number. Tap Continue when finished.

  • If you have an institutional DEA, check the box labeled This is an institutional DEA number with suffix, then select a DEA Schedule (optional).

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9. You have completed your Medical verification. Tap Continue to proceed.  

If your medical credentials were not verified, please use the on-screen prompts to start or schedule a call with ID.me. The most common cause is the nicknames or initials used on paperwork and not because your credentials are truly incorrect. ID.me will manually verify your credentials.

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10. Scroll down and tap Allow to send the on-screen information to iPrescribe. 

  • After your reference authorizes you, you will be prompted to confirm your EPCS activation on your next login. 

3. EPCS Mailer

1. You are almost there.  Review the next steps and tap Next.

2. Validate your DEA address. If it is not current, you will need to update your profile with the DEA.

3. Generate the mailer.

4. Give approximately 10 business days to receive your mailer.

Note: If you requested a hard token to be sent to you, this will be sent separately from the mailer. Your token can be registered after the mailer steps and confirmation of your EPCS are completed.  Please reference How to Manage my EPCS Tokens for details.

5. Once you receive your mailer, log in to iPrescribe, tap the menu button in the top left corner, and select EPCS Activation. You may scan the QR code or enter the 7-digit code

  • To scan the QR code, tap the "Scan QR code" button and give iPrescribe access to your camera, then align the view of the camera with the QR code on the mailer.
  • To enter the code, tap the "Enter 7-digit code" button.

6. Once successful, you will see the Success screen and tap "Next"

4. Confirming my EPCS Activation

Confirm your EPCS activation to finalize and finish the activation process after your reference authorizes you.

  • After your reference authorizes you, you will be prompted to confirm your application's activation on your next login.

1. Follow the steps in chronological order:

(A) Enter your login Password.

(B) Select the Code generator device from the drop-down menu (it will have the nickname you provided).

(C) Enter the 6-digit security code from the Authenticator (ID.me code generator).

If your code fails, go back to the ID.me app and copy a new one. The 6-digit security codes are valid for 30 seconds and then resets as a new code.

(D) Tap Activate before the code changes to a new number.

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2. You can now prescribe controlled substances! 

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  • Please note: the mailer is mailed separately from the hard token.  If you receive the token before receiving your mailer, please keep it in a safe place and complete your registration with the mailer when it arrives.  You may then add the hard token to your profile.

    If you have additional questions, please click Submit a request to create a ticket for DrFirst Support.

    Thank you,


  • Can I have mailer and token be sent to my residential address and not the primary business address listed on DEA?

  • Good afternoon, the mailer is sent to the primary (business) address on file with DEA, so changes to address would have to be processed through the DEA. This is a security measure to ensure compliance with DEA. The hard token, however, can be sent to the address that you were prompted to input during EPCS activation. Therefore, the address for the hard token could be different from that listed with DEA, since you would have entered it manually.